Department 8.1

Medical Measuring Techniques

Research cooperations

Berlin NeuroImaging Center

Multicentric project focussing on the investigation of cerebrovascular diseases and the mechanisms of neurovascular coupling
Charité; Max-Planck-Institut für Bildungsforschung

Berlin ultrahigh field facility

Multicentric initiative to establish an ultrahigh field MR facility with a 7-T whole-body MR scanner at the (MDC) for Molecular Medicine, Berlin-Buch
Max-Delbrück-Centrum; Charité; Forschungsinstitut für Molekulare Pharmakologie

fMRI/NIRS combination for neurological investigations

Use of an MR-compatible NIRS applicator for the investigation of neurovascular coupling
Charité CCM, Klinik für Neurologie; MGH Martinos Center

Paradigm development for fMRI

fMRI-Measurements to investigate the feasibility of a saccade paradigm including a comparison of 1.5 T and 3 T results
Charité CCM, Institut für Psychologie

Multimodal imaging of dopamine-glutamate interaction during reward processing of schizophrenics and healthy controls

Combined measurements of the glutamate concentration in the hippocampus and cingulate cortex by MRS and of BOLD activation in the nucleus accumbens by fMRI
Charité CCM, Klinik für Psychiatrie und Psychotherapie

Dysfunctional reward processing in nicotine dependence and schizophrenia

Application of MRS to investigate why schizophrenic patients are significantly more frequent addicted to nicotine
Charité CCM, Klinik für Psychiatrie und Psychotherapie

MR-spectroscopic detection of glutamate in schizophrenic patients

Development of MR techniques to determine absolute glutamate concentrations in selected regions of the human brain in order to investigate dysfunctional glutamatergic neurotransmission in schizophrenics
Charité CCM, Klinik für Psychiatrie und Psychotherapie

Determination of metabolite concentrations in the brain of depressive patients

Development of NMR techniques to determine absolute metabolite concentrations in selected regions of the brain of depressive patients
Charité CCM, Klinik für Psychiatrie und Psychotherapie

Ultra-broadband medical sensor systems

Development of suitable applicators for radar-based detection of motion artifacts in MRI due to respiration and heart beat together with the development of properly compensating pulse sequences
TU Ilmenau, Abteilung für Elektronische Messysteme und HF-Technik; FSU Jena, Institut für Radiologie

Selective polarization transfer in heteronuclear, coupled spin systems

Development of amplitude modulated, narrow-band radio-frequency pulses for polarization transfer from sensitive to less sensitive NMR nuclei (e.g., ¹H/¹³C)
ETH Zürich, Labor für Physikalische Chemie

Xe spectroscopy as a sensor in molecular biology

Detection of conformation changes in vitro and in vivo by labeling with hyperpolarized ¹²⁹Xe
Forschungsinstitut für Molekulare Pharmakologie

Application of hyperpolarized noble gases for the diagnosis of lung damage after ARDS

MRI investigations using hyperpolarized noble gases on volunteers and recently released patients after acute lung failure together with comparative fluid-dynamical measurements on phantoms
Charité CVK, Klinik für Anaesthesiologie; TU Berlin, Institut für Luft und Raumfahrt

Validation of MR based flow measurements by "Particle Image Velocimetry"

Comparative fluid-dynamical measurements on phantoms by MRI and PIV
TU Berlin, Institut für Luft und Raumfahrt

Investigation of possible CPT-violating effects using hyperpolarized ³He

Pre-studies to detect the extremely long free precession in suitably prepared nuclear spin systems
Uni Mainz, Institut für Physik

12-fold segmented RF volume coil of octahedral symmetry

Assembly and characterization of a new type of head coil for MRI investigations
Uni Leipzig, Interdisziplinäres Zentrum für klinische Forschung

Quantitation of the MR contrast in cellular imaging

Development of MR techniques to quantify the labeling density of endothelial cells in vitro and in vivo for a follow-up study after transplantation of vascular cells in rats
Charité CCM, Institut für Medizinische Immunologie

SUNIMS - Sunphenon Epigallocatechin Gallate (EGCG) in Relapsing Remitting Multiple Sclerosis

MRS measurements of patients suffering from Multiple Sclerosis are cooperatively performed and evaluated within the framework of the "SUNIMS" study on neuro-inflammatory and neuro-degenerative diseases
Charité CCB, Cecilie-Vogt-Klinik für Molekulare Neurologie

Development and implementation of techniques to determine SAR from probe heads for high-field MRI

Development and implementation of cost-effective techniques to simplify and accelerate the safety analysis and certification procedures for newly developed MR at RAPID Biomedical
RAPID Biomedical GmbH

Evaluation of parallel excitation techniques

R&D project in the field of parallel transmission including phantom development, performance tests of multichannel MR coils, and safety analysis of PEX applications in the framework of the French-German INUMAC project
Bruker BioSpin MRI GmbH

Transmit SENSE

Basic developments aiming at the first ever experimental realization of spatially selective excitation in MRI using multi-channel transmit coils
Bruker BioSpin MRI GmbH; Universitätshospital Freiburg

IMAGEN: Reinforcement related behaviour in normal brain function and psychopathology

Cooperation concerning measuring and analyzing fMRI data on 300 volunteers within the European, multicentric IMAGEN study to investigate manifestation and reinforcement of addictive behavior in adolescents
Charité CCM; King's College London; Zentralinstitut für seelische Gesundheit Mannheim; Univ. of Cambridge; CEA Orsay; CNRS, Paris; Uni-Klinik HH-Eppendorf; and more

Cooperation on "Imaging techniques for ultrahigh field MRI systems"

Development, implementation and testing of new procedures and hardware for 7-tesla MR imaging and spectroscopy covering applications in cardiology, oncology, neurology and MR-physics
Siemens AG; Max-Delbrück-Centrum; Charité; Forschungsinstitut für Molekulare Pharmakologie; Deutsches Herzzentrum Berlin

Characterization of an 8-channel head-coil for 7-tesla MRI

Quantitative characterization of an 8-channel 7-tesla head-coil from RAPID Biomedical with respect to SAR and patient safety
RAPID Biomedical GmbH; MPI für Kognitionsforschung, Leipzig, Uni Magdeburg; Universitätshospital Freiburg; Uni Duisburg-Essen

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